YCl3 Promotes Neuronal Cell Death by Inducing Apoptotic Pathways in Rats

نویسندگان

  • Yechun Ding
  • Yuantong Tian
  • Zhaoyi Zeng
  • Ping Shuai
  • Haiying Lan
  • Xianshen Zhu
  • Yi Zhong
  • Longhuo Wu
  • Xiaona Fan
چکیده

The pollutants rare earth elements (REEs) have posed great threats to human health. To investigate the cytotoxicity of yttrium (Y), a model that rats have free access to water containing YCl3 for 6 months is utilized. The results showed that YCl3 treatment promoted neuronal cell apoptosis by upregulating the proapoptotic factors Bax, caspase-3, Cyto c, and DAPK and by downregulating the antiapoptotic factors Bcl-2 and XIAP at both mRNA and protein levels. Conclusively, YCl3 exhibited cytotoxicity and promoted neuronal cell death by the induction of apoptotic pathways.

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عنوان ژورنال:

دوره 2017  شماره 

صفحات  -

تاریخ انتشار 2017